Hepatocarcinoma fibrolamelar un tumor de adultos jóvenes poco frecuente. . Dentro de los diagnósticos diferenciales se debe considerar la HNF, CHC. Protocolo de diagnóstico diferencial de las lesiones ocupantes de espacio en el hígado cirrótico Clinical management of hepatocellular carcinoma. Su diagnóstico suele ser tardío, ya que se presenta en pacientes jóvenes, sin . a las del hepatocarcinoma en la que es necesario un diagnóstico diferencial.

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Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Gd-EOB-DTPA for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging.

The utilization of such contrast agents increases the index of detection of hypo- and hypervascular metastases Figure 7.

Hypovascular metastases with diffusion restriction. Diagnostic accuracy of MRI in differentiating hepatocellular diferenckal from focal nodular hyperplasia: Adenomas are well defined, homogeneous or heterogeneous lesions.

So, hepatobiliary contrast agents combine the pharmacodynamic features of diagnstico gadolinium usual dynamic study with the delayed hepatobiliary phase, adding functional information to the MRI study and enhancing its diagnostic accuracy 124 – 6. The use of hepatobiliary contrast agents requires some care. The hepatobiliary contrast may contribute to the diagnosis of cholecystitis as the gallbladder is not filled by the contrast medium, differently from its habitual behavior with other contrast agents.

Fibrolamellar carcinoma of the liver: Unique phenotype diagnosfico hepatocellular cancers with exon-3 mutations in beta-catenin gene. Two hypervascular lesions arrows are seen with intermediate signal intensity on T1- and T2- weighted sequences, showing contrast uptake in the hepatobiliary-phase. Such lesions present functioning hepatocytes, suggesting FNHs as the main diagnostic hypothesis and ruling out the possibility of metastatic implants.

HEPATOCARCINOMA DE CÈLULAS CLARAS by marta garnica ureña on Prezi

As the gadoxetic acid dose corresponds to one quarter of the habitual extracellular gadolinium dose, the arterial phase acquisition time is critical, requiring temporal precision methods, such as real time visualization of the contrast progression through the arterial system, for the success in this phase acquisition. Hemangiomas generally present typical imaging findings and are easily diagnosed by diferenial tomography or MRI with extracellular gadolinium contrast agent.


Fibrolamellar hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus, and pulmonary emboli. Imaging findings in the hepatobiliary findings should be always analyzed in the clinical context, considering the lesion signal characteristics on anatomical sequences.

However, the differentiation between FNH and adenoma is not always easy at conventional MRI, because both conditions may appear as nonspecific hypervascular lesions, generating anguish for the patient and challenging the physician, in addition to the cost and patient’s anxiety with repeated examinations. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Progres dans les recherches sur le cancer ; Advances in anatomic pathology ; 14 3: On the other hand, poorly-differentiated or undifferentiated hepatocarcinomas do not contain functioning hepatocytes and do not show hepatobiliary contrast uptake, remaining hypointense in relation to the surrounding parenchyma 21017 – 19 Figure 6. Hepatobiliary contrast allows for the differentiation between biliary lesions and extrabiliary cysts, since it delineates the biliary tract, demonstrating the communication of biliary cystic lesions with the bile ducts, and extrabiliary cystic lesions that do not communicate with bile ducts, such as pseudocysts, duodenal diverticula and duodenal duplication cysts 5.

Thus, in the hepatobiliary phase, most adenomas are hypointense in relation to the surrounding parenchyma Figure 3. Abstract Fibrolamellar hepatocarcinoma is a rare neoplasm diagnosed by computed tomography and confirmed by anatomopathological examination.

Belo Horizonte, MG, Adverse effects of hepatobiliary contrast agents rarely occur and, if present, are similar to the ones reported in the use of extra-cellular gadolinium.

The utilization of hepatobiliary contrast agents increases the MRI accuracy, reducing the necessity of invasive diagnostic procedures intended to clarify the diagnosis doagnostico nonspecific lesions 12.

Hemangiomas are formed by a clump of blood vessels and do not contain hepatocytes, therefore they do not present contrast enhancement during the hepatobiliary phase and appear hypointense in this phase 12915 Figure 4. As gadoxetic acid is utilized, the hepatobiliary phase occurs in 20 minutes, so it is recommended that the order of sequences acquisition be changed in order to optimize the hepatocwrcinoma time.


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Poorly differentiated or undifferentiated HCCs do not contain functioning hepatocytes so hepatobiliary contrast uptake is not observed. Also, in the delayed-phase, the fill-in pattern is not observed, diagnkstico might occur with the utilization of hepatobiliary contrast agent.

In cirrhosis, hepatocytes are progressively replaced by fibrotic tissue, so that the more advanced the fibrosis, the smaller the hepatic parenchyma enhancement in the hepatobiliary phase. Considering that the presence of intralesional fat in NFH is rare, the patient will be maintained under imaging follow-up.

How to cite this article. Services on Demand Article. Two liver nodules are seen in the segment VIII arrows as well as a larger nodule, in the segment VI arrowheadsall of them contrast-enhanced in the arterial-phase, washout in the delayed-phase, and without uptake in the hepatobiliary-phase, characterizing HCCs.

Perfusional alterations present a signal similar to the one of the remainder hepatic tissue during the portal and hepatobiliary phases, while most HCCs, except the well-differentiated ones, present hyposignal in the hepatobiliary phase This article has been cited by other articles in PMC.

FNH is a benign lesion that does not require any intervention, while adenoma presents risk for malignization, necrosis and bleeding which might require emergency surgery. Hepatology ; 39 3: Hepatobiliary contrast allow for the differentiation between FNH and adenoma in most cases, even in those of small lesions.

However, considering that hemangiomas are common lesions, they will be frequently present on images acquired with hepatobiliary contrast for several reasons. However, in some cases, especially those of small lesions without central scarone cannot differentiate between FNH and adenoma due to overlapping imaging findings 14.

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